International Journal Of Engineering Technology And Management Sciences

AUTHOR(S)

Pavan Raju, Amrutha Bhat, Sindhu S., Sushmitha A.C.,Dr. Sindhu Sree M., Dr. Pavithra G., Dr. T.C.Manjunath, Aditya T.G., Sandeep K.V., Rajashekar M. Koyyeda, Dr. Suhasini V.K., Dr. Vijayakumar K.N.

DOI: https://doi.org/10.46647/ijetms.2023.v07i01.046

ABSTRACT
This paper gives the details about the development of Nano Route Based Synthetic RBCs. Blood plays an important role in the survival and functioning of Human body. Blood is required in various treatments during surgeries and loss of blood can cause several problems. World is facing problems due to shortage of blood. Synthetic RBC (Artificial blood) is a safe alternative for Human RBC using nano-technology. It can used instead of human blood during the blood transfusions to overcome the shortage of human blood. The main function of Synthetic RBC is to transport oxygen. Synthetic RBC mimics the actions of human RBC like ability to clot and react to pathogens. The work given here is a mini-project that is taken up as a part of the curriculum completed by electronics and communication engineering students in the second year of the electronics & communication engineering department at Dayananda Sagar College of Engineering in Bangalore.

Page No: 309 - 314

References:

1. Suman Sarkar, Artificial blood; Indian J Crit Care Med July-September 2008.
2. Singh Neelam Artificial blood: A tool for survival of humans; International Research Journal Of Pharmacy.
3. Clinical Use of a Blood Substitute. (1980). New England Journal of Medicine, 303(7), 391–392.
4. R. K. Spence md, D. Norcross md perfluorocarbons as blood substitutes: The early years. Experience with fluosol da-20% in the 1980s 1994
5. Mercy Paul. A Review on Artificial Blood. Journal of Blood Disorders & Transfusion, 2021.
6. Johannes Jägers1 & Anna Wrobeln1 & Katja B. Ferenz1,. Perfluorocarbon-based oxygen carriers: from physics to physiology  2021
7. Cronin, William A.; Hall, Aaron A.; Auker, Charles R.; Mahon, Richard T. Aerospace Medicine and Human Performance, Volume 89, Number 1, January 2018, pp. 14-18(5)
8. Katja B. Ferenz and Andrea U. Steinbicker : Artificial Oxygen Carriers—Past, Present, and Future—a Review of the Most Innovative and Clinically Relevant Concepts ;Journal of Pharmacology and Experimental Therapeutics May 2019, 369 (2) 300-310
9. Fraker, C. A., Mendez, A. J., Inverardi, L., Ricordi, C., & Stabler, C. L. Optimization of perfluoro nano-scale emulsions: The importance of particle size for enhanced oxygen transfer in biomedical applications ;Elsevier 2012. 
10. R. Devi Priya, R. Sivaraj, Ajith Abraham, T. Pravin, P. Sivasankar and N. Anitha. "Multi-Objective Particle Swarm Optimization Based Preprocessing of Multi-Class Extremely Imbalanced Datasets". International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems Vol. 30, No. 05, pp. 735-755 (2022). Doi: 10.1142/S0218488522500209
11. Deshmukh K P. "Wireless Transceiver Module HC-12 based Automatic Water-level Monitoring and Control System". International Research Journal on Advanced Science Hub, 2, 10, 2020, 24-28. doi: 10.47392/irjash.2020.184
12. Naveenkumar S; Kirubhakaran R; Jeeva G; Shobana M; Sangeetha K. "Smart Health Prediction Using Machine Learning". International Research Journal on Advanced Science Hub, 3, Special Issue ICARD-2021 3S, 2021, 124-128. doi: 10.47392/irjash.2021.079
13. Hari Prasada Raju Kunadharaju; Sandhya N.; Raghav Mehra. "Detection of Brain Tumor Using Unsupervised Enhanced K-Means, PCA and Supervised SVM Machine Learning Algorithms". International Research Journal on Advanced Science Hub, 2, Special Issue ICSTM 12S, 2020, 62-67. doi: 10.47392/irjash.2020.262
14. Sona Solanki; Asha D Solanki. "Review of Deployment of Machine Learning in Blockchain Methodology". International Research Journal on Advanced Science Hub, 2, 9, 2020, 14-20. doi: 10.47392/irjash.2020.141
15. Shreekar Kolanu; Shikhar Jyoti Dutta; Saurav Roy; Maheswari M.. "A Diabetic Diet Suggester and Appointment Scheduler Chatbot using Artificial Intelligence and Cloud". International Research Journal on Advanced Science Hub, 3, Special Issue 6S, 2021, 77-81. doi: 10.47392/irjash.2021.170
16. Praveen Kumar Mishra; Prabhakar Tiwari. "Cyber Security in Smart Grid". International Research Journal on Advanced Science Hub, 2, 6, 2020, 26-30. doi: 10.47392/irjash.2020.33
17. Salini Suresh; Suneetha V; Niharika Sinha; Sabyasachi Prusty. "Latent Approach in Entertainment Industry Using Machine Learning". International Research Journal on Advanced Science Hub, 2, Special Issue ICARD 2020, 2020, 304-307. doi: 10.47392/irjash.2020.106
18. Gayathri N Shenoy; Chithu Rajan; Shibi Varghese; Vignesh M.V; ShanmugaPriya M; Priya S; Aparna George. "STERILOID: Room Sanitization Robot". International Research Journal on Advanced Science Hub, 2, 8, 2020, 100-104. doi: 10.47392/irjash.2020.101
19. Mohan Kumar B.N; Rangaraju H.G. "Array Multiplier and CIA based FIR Filter for DSP applications". International Research Journal on Advanced Science Hub, 3, Special Issue ICEST 1S, 2021, 52-59. doi: 10.47392/irjash.2021.020
20. T. Pravin, C. Somu, R. Rajavel, M. Subramanian, P. Prince Reynold, Integrated Taguchi cum grey relational experimental analysis technique (GREAT) for optimization and material characterization of FSP surface composites on AA6061 aluminium alloys, Materials Today: Proceedings,Volume 33, Part 8, 2020, Pages 5156-5161, ISSN 2214-7853. doi.org/10.1016/j.matpr.2020.02.863.
21. Freire, M. G., Carvalho, P. J., Queimada, A. J., Marrucho, I. M., & Coutinho, J. A. P. Surface Tension of Liquid Fluorocompounds. Journal of Chemical & Engineering Data, 51(5) 2006 
22. Hill, S. E. Perfluorocarbons. SHOCK, 2017
23. Jahr, Jonathan S. MD, FASA; Guinn, Nicole R MD; Lowery, David R. MD; Shore-Lesserson, Linda MD, FAHA, FASE; Shander, Aryeh MD, FCCM, FCCP, FASA, Blood Substitutes and Oxygen Therapeutics: A Review. 2021
24. Johannes Jägers & Anna Wrobeln & Katja B. Ferenz, Perfluorocarbon-based oxygen carriers: from physics to physiology 2021
25. Clark, L. C., & Gollan, F.  Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure. Science, 152(3730), 1755–1756. 1966
26. R M Engelman, J H Rousou, W A Dobbs Fluosol-Da: An Artificial Blood for Total Cardiopulmonary Bypass. The Annals of Thoracic Surgery, 32(6), 528–535.
27. R. Devi Priya, R. Sivaraj, Ajith Abraham, T. Pravin, P. Sivasankar and N. Anitha. "Multi-Objective Particle Swarm Optimization Based Preprocessing of Multi-Class Extremely Imbalanced Datasets". International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems Vol. 30, No. 05, pp. 735-755 (2022). Doi: 10.1142/S0218488522500209
28. Deshmukh K P. "Wireless Transceiver Module HC-12 based Automatic Water-level Monitoring and Control System". International Research Journal on Advanced Science Hub, 2, 10, 2020, 24-28. doi: 10.47392/irjash.2020.184
29. Naveenkumar S; Kirubhakaran R; Jeeva G; Shobana M; Sangeetha K. "Smart Health Prediction Using Machine Learning". International Research Journal on Advanced Science Hub, 3, Special Issue ICARD-2021 3S, 2021, 124-128. doi: 10.47392/irjash.2021.079
30. Hari Prasada Raju Kunadharaju; Sandhya N.; Raghav Mehra. "Detection of Brain Tumor Using Unsupervised Enhanced K-Means, PCA and Supervised SVM Machine Learning Algorithms". International Research Journal on Advanced Science Hub, 2, Special Issue ICSTM 12S, 2020, 62-67. doi: 10.47392/irjash.2020.262
31. Sona Solanki; Asha D Solanki. "Review of Deployment of Machine Learning in Blockchain Methodology". International Research Journal on Advanced Science Hub, 2, 9, 2020, 14-20. doi: 10.47392/irjash.2020.141
32. Shreekar Kolanu; Shikhar Jyoti Dutta; Saurav Roy; Maheswari M.. "A Diabetic Diet Suggester and Appointment Scheduler Chatbot using Artificial Intelligence and Cloud". International Research Journal on Advanced Science Hub, 3, Special Issue 6S, 2021, 77-81. doi: 10.47392/irjash.2021.170
33. Praveen Kumar Mishra; Prabhakar Tiwari. "Cyber Security in Smart Grid". International Research Journal on Advanced Science Hub, 2, 6, 2020, 26-30. doi: 10.47392/irjash.2020.33
34. Gayathri N Shenoy; Chithu Rajan; Shibi Varghese; Vignesh M.V; ShanmugaPriya M; Priya S; Aparna George. "STERILOID: Room Sanitization Robot". International Research Journal on Advanced Science Hub, 2, 8, 2020, 100-104. doi: 10.47392/irjash.2020.101
35. T. Pravin, C. Somu, R. Rajavel, M. Subramanian, P. Prince Reynold, Integrated Taguchi cum grey relational experimental analysis technique (GREAT) for optimization and material characterization of FSP surface composites on AA6061 aluminium alloys, Materials Today: Proceedings, Volume 33, Part 8, 2020, Pages 5156-5161, ISSN 2214-7853. doi.org/10.1016/j.matpr.2020.02.863.
36. Mohan Kumar B.N; Rangaraju H.G. "Array Multiplier and CIA based FIR Filter for DSP applications". International Research Journal on Advanced Science Hub, 3, Special Issue ICEST 1S, 2021, 52-59. doi: 10.47392/irjash.2021.020
37. Gary W Latson  ; Perftoran (Vidaphor)-Introduction to Western Medicine2019.
38. Shreekar Kolanu; Shikhar Jyoti Dutta; Saurav Roy; Maheswari M.. "A Diabetic Diet Suggester and Appointment Scheduler Chatbot using Artificial Intelligence and Cloud". International Research Journal on Advanced Science Hub, 3, Special Issue 6S, 2021, 77-81. doi: 10.47392/irjash.2021.170
39. Gould, S. A., Rosen, A. L., Sehgal, L. R., Sehgal, H. L., Langdale, L. A., Krause, L. M., … Moss, G. S. ;Fluosol-DA as a Red-Cell Substitute in Acute Anemia. New England Journal of Medicine, 314(26), 1653–1656.1986
40. Zhengwen Zhou , Wilson P Daugherty, Dong Sun, Joseph E Levasseur, Nabil Altememi, Robert J Hamm, Gaylan L Rockswold, M Ross Bullock ; Protection of mitochondrial function and improvement in cognitive recovery in rats treated with hyperbaric oxygen following lateral fluid-percussion injury;2008
41. Kaitlin Graham , Paula F Moon-Massat , Evan C Unger Dodecafluoropentane Emulsion (DDFPE) as a Resuscitation Fluid for Treatment of Hemorrhagic Shock and Traumatic Brain Injury: A Review;Shock 2019
42. Johnson JLH: Chapter 26, Oxygen Carriers: Are they enough for cellular support? Neuroprotective Therapy for Stroke and Ischemic Disease. Springer International Publishing Switzerland. 621-640, 2017
43. Sheppard RL, Regis DP, Mahon RT: Dodecafluoropentane (DDFPe) and Decompression Sickness-related Mortality in Rats. Aerospace medicine and Human Performance 86(1): 21-26, 2015.
44. Graham, K., Moon-Massat, P. F., & Unger, E. C. Military Supplement. SHOCK 2017


How to Cite This Article:
Pavan Raju, Amrutha Bhat, Sindhu S., Sushmitha A.C.,Dr. Sindhu Sree M., Dr. Pavithra G., Dr. T.C.Manjunath, Aditya T.G., Sandeep K.V., Rajashekar M. Koyyeda, Dr. Suhasini V.K., Dr. Vijayakumar K.N. . Development of Nano Route Based Synthetic RBC . ijetms;7(1):309-314. DOI: 10.46647/ijetms.2023.v07i01.046