International Journal of Engineering Technology and Management Sciences

2023, Volume 7 Issue 2

Phytoalexins: Defend systems of plants and Pharmacological Potential - A systematic review

AUTHOR(S)

T.Sivakumar, B.Deepa

DOI: https://doi.org/10.46647/ijetms.2023.v07i02.039

ABSTRACT
Plants are easily prone towards microbial infections on exposure to microorganisms and pathogens. In order to defense, plants produce low molecular weight secondary metabolites which were later known as “Phytoalexins”. These molecules have vast therapeutic potential also. The purpose of this review is to explore the phytoalexins and their pharmacological effects. The data included from the articles were published from PubMed, Web of Science, Medline, Scopus, and Embase by using relevant keywords including plants possessing phytoalexins and their specific biological applications. phytoalexins started with progress in their biochemistry and bioorganic chemistry, resulting in the determination of their structure, their biological activity, as well as mechanisms of their synthesis and catabolism by microorganisms. This has led to potential applications for increasing plant resistance to diseases. Phytoalexins exhibit an enormous diversity belonging to various chemical families such as for instance, phenolics, terpenoids, furanoacetylenes, steroid glycoalkaloids, sulfur-containing compounds and indoles. phytoalexins are used in the various diseases and applications of plants and human health. Based on this review, it can be concluded that phytoalexins have tremendous potential in the treatment and prevention of various life-threatening diseases such as diabetes, cancer, brain damage and heart attack.

Page No: 319 - 326

References:

1.Durango D, Pulgarin N, Echeverri F, Escobar G, Quiñones W. Effect of salicylic acid and structurally related compounds in the accumulation of phytoalexins in cotyledons of common bean (Phaseolus vulgaris L.) cultivars. Molecules. 2013; 18: 10609-10628.
2.Cabral LC, Pinto VF, Patriarca A. Application of plant derived compounds to control fungal spoilage and mycotoxin production in foods. Int J Food Microbiol. 2013; 166: 1-14.
3.Agrios GN. Plant pathology, 5th edn. Academic Press, Elsevier.2005.
4. Li Y1, Nie Y, Zhang Z, Ye Z, Zou X, Zhang L. Comparative proteomic analysis of methyl jasmonateinduced defense responses in different rice cultivars. Proteomics. 2014; 14: 1088-1101.
5. Singh R, Chandrawat KS. Role of phytoalexins in plant disease resistance. Int J Curr Microbiol App Sci. 2017; 6: 125-129.
6. Jiang L, Wu J, Fan S, Li W, Dong L, Cheng Q. Isolation and characterization of a novel pathogenesis-related protein gene (GmPRP) with induced expression in soybean (Glycine max) during infection with Phytophthora sojae. PLoS ONE. 2015; 10: 1-13.
7. Sharma A, Sharma A, Kumar R, Sharma I, Vats AK. PR proteins: key genes for engineering disease resistance in plants. In: Kumar P, Thakur AK (eds) Crop improvement: biotechnological advances. CRC Press,2021; pp 81–98
8. Llorens E, Garcı´a-Agustın P, Lapeña L. Advances in induced resistance by natural compounds: towards new options for woody crop protection. Sci Agri 2017; 74: 90-100.
9. Chripkova M, Zigo F, Mojzis J. Antiproliferative effect of indole phytoalexins. Molecul. 2016;21(12):1626.
10. Muller KO, Meyer G, Klinkowski M. Physiologischgenetische Untersuchungen über die Resistenz der Kartoffel gegenüber Phytophthora infestans. Naturewissenschaften. 1937; 27(46):765-768.
11. Muller K. Experimentelle untcrsuchungcn uber die Phytophthora-resistem der kartoffel. Arb Biol Reichsasnstalt Landw Forstw Berlin.1940; 23:189-231
12. Muller KO, Borger H. Experimentelle Untersuchungen Uber die Phytophthora infestans Resistenz der Kartoffel. Arb Biol Reichsanst Land Forstwirtsch.1940; 97:189-231.
13. Pedras MSC, Zheng QA, Sarma-Mamillapalle VK. The phytoalexins from Brassicaceae: structure, biological activity, synthesis and biosynthesis. Nat Product Commun.2007; 2(3): 319-330.
14. Hammerschmidt R. Phytoalexins: what have we learned after 60 years? Annual Rev Phytopathol. 1999;37(1): 285-306.
15. Suman, S. Plant tissue culture: A promising tool of quality material production with special reference to micropropagation of banana. Biochem Cell Architech. 2017;17 (1): 1-26.
16. Deepa B, Sivakumar T. Phytochemical Analysis and Antibacterial Efficacy of Ethanolic Extract of Musa paradisiaca. Res Biotica Int J. 2020; 2: 126-130.
17. Angelin JJ, Jothi U, Thiyagarajan G, Sivakumar T. Evaluation of antimicrobial activity and phytochemicals analysis of whole plant extract of Vinca rosea. Asian J of Pharma Clin Res. 2019; 12:132-136.
18. Sivakumar T. Synthesis of silver nanoparticles using Cassia auriculata leaf extracts and their potential antidiabetic activity. Int J Bot Studies. 2021;6(3): 35-38.
19. Sivakumar T. A modern review of silver nanoparticles mediated plant extracts and its potential bioapplications. Int J Bot Studies. 2021;6(3):170-175.
20. Sivakumar T. Invitro antioxidant, total phenolic, total flavonoid content and biosynthesis of silver nanoparticles by Cassia auriculata leaves extracts. Int J Bot Studies.2021;6(3):476-480.
21. Sivakumar T. A review on biosynthesis of Zinc Oxide Nanoparticles using plant extracts and its potential Bio Applications. International Journal of Botany Studies. Int J Bot Studies.2021;6(3):644-648.
22. Angelin JJ, Jothi U, Thiyagarajan G, Subramanian VK, Sivakumar T. Estimation of qualitative and quantitative analysis of antioxidant activity of different parts of Catharanthus roseus (L). Plant Arch. 2020; 20: 4187-4192.
23. Sivakumar T, Deepa B. A review on some folk medicinal plants and their common uses, Res Biotica Int J. 2020; 3:131-134.
24. Thiyagarajan G, Sivakumar T. A review on Pepper and their common phytochemicals. Res Biotica Int J.2020; 2: 149-153.
25. Senthilkumar SR, Sivakumar T, Arulmozhi KT, Mythili N. Gas chromatography Mass spectroscopy evaluation of bioactive phytochemicals of commercial green teas (Camellia sinensis) of India. Asian J Pharm Clin Res. 2015; 8: 278-282.
26. Sivakumar T, Panneerselvam R. Triadimefon mediated changes in antioxidant and indole alkaloid content in two species of Datura. Amer J Plant Physiol. 2011; 6: 252-260.
27. Sivakumar T. Phytochemical screening and GC- MS analysis of bioactive compounds and biosynthesis of silver nanoparticles using sprout extracts of Vigna radiate L. and their antioxidant and antibacterial activity. Asian J Pharm Clin Res. 2019;12(2):180-184.
28. Sivakumar T, Sundaramanickam A, Panneerselvam R. Changes in growth and pigment content in sweet potato by Triadimefon and Hexaconazole. J Phytol. 2009; 1:333-341.
29. Sivakumar T, Alagu Lakshmanan GM, Murali PV, Panneerselvam R. Alteration of antioxidative metabolism induced by triazoles in Sweet Potato. J Exper Sci. 2010; 1: 10-13.
30. Jothi U, Angelin JJ, Sivakumar T. Study on Estimation and Antioxidant activity of Gloriosa superba L. Whole Plant Extract. Int J Sci Res Biol Sci. 2019;6(3):55-58.
31. Senthilkumar SR, Sivakumar T, Arulmozhi KT, Mythili N. FT-IR analysis and correlation studies on the antioxidant activity, total phenolics and total flavonoids of Indian commercial teas (Camellia sinensis L.) - A novel approach. Int Res J Biol Sci.2017; 6(3): 1-7.
32. Senthil Kumar SR, Sivakumar T, Arulmozhi KT, Mythili N. Antimicrobial Activity of Indian Commercial Green Teas (Camellia Sinensis). Int J Biosci Nanosci.2016;3(7): 108-112.
33. Senthilkumar SR, Sivakumar T. Green tea (Camellia sinensis) mediated synthesis of zinc oxide (ZNO) nanoparticles and studies on their antimicrobial activities. Int J Pharm Pharmaceut Sci. 2014;6(6): 461-465.
34. Senthilkumar SR, Sivakumar T. Studies on the Greengram (Vigna radiata L.) Sprout Assisted Synthesis of Silver Nanoparticles and their Antimicrobial Activities. Int J Nanomat Biostru. 2014;4(3): 52-57.
35.Shanmugapriya AK, Sivakumar T, Panneerselvam R. Study of antioxidant potentiality of tomato under tricyclazole and difenoconazole treatments. Int J Res Plant Sci. 2013; 3: 47-53.
36. Huang DD, Shi G, Jiang Y, Yao C, Zhu C. A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications. Biomed Pharmacotherapy. 2020;125:109767.
37. Deepa B, Sivakumar T. Screening of Phytochemicals and in vitro studies of Garlic: An Updated review. Int J of Eng Tech Manag Stud.2023;7(1-2): 6-11.
38. Sivakumar T, Deepa B. A critical review on Antidiabetic Potential of Herbal plants and its their bioactive components. J Univer Shanghai Sci Tech. 2023;25(01)303-314.
39. Ozturk E, Arslan AKK, Yerer MB, Bishayee A. Resveratrol and diabetes: A critical review of clinical studies. Biomed Pharmacother. 2017;95: 230-234.
40. Kumar A, Kaundal RK, Iyer S, Sharma SS. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy. Life Sci. 2007;80(13): 1236-1244.
41. Sharma S, Kulkarni SK, Chopra K. Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Fund Clin Pharm.2007; 21(1): 89-94.
42. Soufi FG, Mohammad-nejad D, Ahmadieh H. Resveratrol improves diabetic retinopathy possibly through oxidative stress—Nuclear factor κb—Apoptosis pathway. Pharm Reports.2012; 64(6), 1505-1514.
43. Hamadi N, Mansour A, Hassan MH, Khalifi-Touhami F, Badary O. Ameliorative effects of resveratrol on liver injury in streptozotocin-induced diabetic rats. J Biochem Mole Toxicol. 2012;26(10): 384-392.
44. Rauf A, Imran M, Butt MS, Nadeem M, Peters DG, Mubarak MS. Resveratrol as an anticancer agent: A review. Crit Rev Food Sci Nut. 2018; 58(9):1428-1447.
45. Mehta RG, Liu J, Constantinou A, Thomas CF, Hawthorne M, You M, Gerhauser C, Pezzuto JM, Moon RC, Moriarty RM. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogen. 1995; 16(2): 399-404.
46.Abdel-Latif GA, Al-Abd AM, Tadros MG, Al-Abbasi FA, Khalifa AE, Abdel-Naim AB. The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep. 2015; 5: 12054.
47. Riles WL, Erickson J, Nayyar S, Atten MJ, Attar BM, Holian O. Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells. World J Gastroenterol. 2006; 12(35): 5628- 5634.
48.Kiskova T, Kubatka P, Büsselberg D, Kassayova M. (2020). The Plant-Derived Compound Resveratrol in Brain Cancer: A Review. Biomol.2020; 10(1): 161.
49. Pham TH, Lecomte S, Efstathiou T, Ferriere F, Pakdel F. (2019) An update on the effects of glyceollins on human health: possible anticancer effects and underlying mechanisms. Nutrients. 2019;11(1):79
50. Smith BA, Neal CL, Chetram M, Vo B, Mezencev R, Hinton C, Odero-Marah VA. (2013) The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species. J Nat Med. 2013;67(3):607–618
51.Chripkova M, Zigo F, Mojzis J. Antiproliferative effect of indole phytoalexins. Mole.2016; 21(12):1626
52. Stompor M. A review on sources and pharmacological aspects of sakuranetin. Nutrients.2020; 12(2):513.
53. Sivakumar T, Panneerselvam R. Salinity induced changes in photosynthetic pigment and antioxidant responses in Sesuvium portulacastrum. Pak J Biol sci. 2011; 14 (21):967-975.
54. Sivakumar T. A systematic review on traditional medicinal plants used for traditional control of insects. Int J Bot Stud.2022;7(12):32-36.
55. Sivakumar T. A recent review on phytochemicals commonly found in herbal plants. Int J Bot Stud. 2022;7(12): 54-57.


How to Cite This Article:
T.Sivakumar, B.Deepa . Phytoalexins: Defend systems of plants and Pharmacological Potential - A systematic review . ijetms;7(2):319-326. DOI: 10.46647/ijetms.2023.v07i02.039